The team of scientists from the MIPT, the Scientific Center for Obstetrics, Gynecology and Perinatology. Academician VI Kulakov, the Institute of Biochemical Physics, Russian Academy of Sciences and the Institute for Energy Problems of Chemical Physics has developed an approach to create a method of non-invasive diagnosis of pregnant women suffering from serious complex diseases -. preeclampsia
Simply put, researchers found biomarkers in urine pregnant women, which signal a potential danger for the mother and her fetus. The diagnostic method is based on a urine test will allow in the future to identify the disease in its earliest stages
Pre-eclampsia -. it is a multisystem disorder arising in the second half of pregnancy and is characterized by hypertension and proteinuria (a significant increase in protein content in the urine of women) . In this state, the expectant mother suffers from headaches, swelling, fainting, and other unpleasant and sometimes dangerous symptoms. As a result, pre-eclampsia exposes the health and even the life of the expectant mother and her child at serious risk
“The symptoms of disease are ambiguous, so doctors rarely diagnose a” clean “preeclampsia But even if such a diagnosis is made, a new problem arises:.. The causes of this disorder is still unknown, so it is impossible to effectively deal with it “, – says Natalya Starodubtseva, an employee of the Department of molecular physics MIPT and head of the Laboratory of proteomics of human reproduction FGBU NC Agip them. VI Kulakov.
In other words, doctors are forced to prescribe supportive care, remove the symptoms, trying to delay the birth of a child, while balancing between the desire to give him more time for full fetal development (although it also suffers iz due to improper formation of the placenta) and the desire to preserve the mother’s health.
But medicine does not stand still. Once something goes wrong “on all fronts” of the body, it is logical to assume that the failure of systems at the molecular level piskhodit. The researchers decided to look for early signs of disease in the urine (a non-invasive, ie without interfering with the work of the body, the method is very convenient for examination expectant mothers).
It should be noted that even in the urine of a healthy person there is absolutely proteins. However, in very small concentrations. For physicians as one of the main symptoms of pre-eclampsia is a marked increase in the concentrations of these substances. The normal 0.03 g / l to the critical 0.3 g / l and higher
Scientists thinking may if peptides (pieces proteins), which are allocated among women suffering from preeclampsia carry information about the disease.
To identify potential biomarkers of peptides, the researchers compared the samples of three groups of patients of the Scientific center for Obstetrics, gynecology and Perinatology. Academician VI Kulakov:. A woman with a normal pregnancy, with moderate to severe forms of preeclampsia
That is, the researchers wanted to compare not only the sick and the healthy pregnant women, but also to see how these or other associated biomarkers with severity of the condition. After processing the results of experiments 35 peptide biomarker of preeclampsia was found. Among them are, for example, fragments of alpha-1-antitrypsin (14 peptides), alpha-chains of collagen I and type III (6 peptides) and uromodulina (7 peptides).
“We were able to confirm the number of markers, . previously proposed foreign colleagues, as well as show off some new obvious need to check and confirm their significance is important that developed a non-invasive method has proven effective:. on this basis, you can develop a clinical diagnostic method “, – commented on the results of research Alex Kononikhin, Deputy head of the Laboratory ionic and molecular physics MIPT.
The article Russian scientists was published in the Journal of Proteomics.
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