Scientists have discovered a mechanism that “trigger” of Alzheimer’s disease – BBC

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An international team of scientists, with the participation of researchers from MSU. MV Lomonosov Moscow State University and Institute of Molecular Biology to understand the mechanisms of Alzheimer’s disease and perhaps has found the mechanism that initiates the process of its emergence. An article about this study published in the journal Scientific Reports.

mechanism of the disease of Alzheimer’s is dedicated to several hypotheses. One of the most common is considered amyloid hypothesis. Amyloids – or beta-amyloid peptides – representing the molecular structure of the protein and the type normally employed in the protection of cerebral nerve cells. But sometimes there comes a time when nerve cells are transformed into defenders of their killers. Detail the mechanism established by the steps inherent in the disease in the advanced stage, when there are toxic aggregates and the brain is covered by amyloid plaques. On the initial stage of the process, very little was known.

Scientists have investigated various pathogenic beta amyloid peptides, or rather, their short segments, domains, linking them with metals. One of the pathogens was so-called “English mutant”, which differs from the normal beta-amyloid peptide of only one amino acid substitution. Another pathogen was isomerized beta-amyloid peptide. It is the chemical composition does not differ from normal, but one of its amino acid residues is a molecule with a different mutual arrangement of atoms.

The authors of the work we found out that, despite all the differences in the processes occurring with “English mutant “and isomerized peptide, the initial stages of plaque formation they were exactly the same: in both cases, the role of pathogenic aggregation nuclei played pathogenic dimer peptide – two peptide molecules bonded zinc ion

on the basis of this similarity, the researchers developed alleged. controlled mechanism of zinc ions peptide defender transformation procedures in peptide-killer. This mechanism, the researchers note, explains many experimental facts obtained not only by them but also by their colleagues in other laboratories studying Alzheimer’s disease. Scientists also hope their discovery by accurately selecting the target will help to create new drugs capable of blocking initialized ions zinc aggregation of beta-amyloid peptides

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